Halo® column packings are not made the typical way. Instead, the particles packed into HALO® columns are manufactured using Fused-Core® particle technology that was specially developed to deliver hyper-fast chromatographic separations while avoiding the reliability issues so often associated with fast HPLC.
The shorter diffusion path of HALO® particles reduces axial dispersion of solutes and minimizes peak broadening. A Halo particle has only a 0.5 ?m diffusion path compared to the approximately1.5 ?m diffusion path of a 3 ?m totally porous particle. Because of the shorter diffusion path, the performance advantages of HALO® become even more apparent when separating larger solute molecules and operating at faster mobile phase flow rates.
Their ability to generate hyper-fast separations comes not only from their small particle size (2.7 ?m) but also from the unique Fused-Core® particle technology that creates a 0.5 ?m porous shell fused to a solid core particle. As you increase mobile phase flow rate to speed-up a separation, the slow mass transfer of solute molecules inside the particles can limit resolving power. Fused-Core® particle technology addresses this limitation by providing an incredibly small path (0.5 ?m) for diffusion of solutes into and out of the particles, thereby reducing the time solute molecules spend inside the particles and minimizing a major barrier to fast chromatographic separations.
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